Basic
of pharmacology
(cholinergic agonist)
Parasympathetic
=
acetylcholine
tow part :
direct and
indirect
.
.
.
Direct
:
1-acetylcholine
Receptors :
*nicotinic
*muscarinic
Action
::
*Increased
secretion in the mouth
*decreased
heart rate
*Increased
secretion gastric and salivation
*Increased intestinal motility
Increased salivat *
Uses :
Not used
2- bethanchol
Receptors:
Muscarinic ..in the bladder and intestinal
Action :
: like actylcholine
Uses :
atonic bladder..post partum -atonic
bowel..post
operatine
S .E:
I thing no adverse effects
3-Carbachol
Receptors:
*muscarinic
nicotinic *
Action :
like actylcholine
Uses :
Glaucoma
S.E :
C N S
4- pilocarbine
Receptors:
*muscarinic
Action:
Uses :
Glucoma as emergency
S.E : C N S
Cholinergic agonist
( Indirect )
Reversible
1-physo-stigmine
Duration:
2_4 hours
Uses :
*Atonic
bladder –>post partum
*Atonic
intestine à post peratine
* Glucoma
*Antidol of antcholinergic drug
S.E :
convulsion and CNS
2-Neo-stigmine
Duration :
2-4 hours
Uses :
*antidote muscular
Myasthenia
gravis *
3-phrido-stigmine
Duration :
3-6 hours
Uses :
chronic use for Myasthenia gravis
4- Edrophorium
Duration :
10-20 min
Uses :
*diagnostic of masthmia
Antidot of atropine *
Irreversible
1-echothiophate .
2-Isoflurophate .
Uses :
glaucoma
كاتبة بتول
الموضوع : Basic of pharmacology المصدر :منتديات تقى الإسلامية الكاتب: El Helalya
